Dr. Sebastiano Di Bucchianico

Research topics

  • Aerosol Toxicology and Mutagenesis
  • Primary and Secondary Genetic Toxicology
  • Nanotoxicology
  • Air-Liquid Interface In Vitro models for airborne Particulate Matter exposures


  • Since 2019 Aerosol Mutagenesis Research Group Leader at Helmholtz Centre Munich – cooperation group Comprehensive Molecular Analytics, and Habilitation candidate at Chair of Analytical Chemistry, University of Rostock
  • 2017-2019 Scientist at Helmholtz Centre Munich – cooperation group Comprehensive Molecular Analytics
  • 2016-2017 Research fellow at the Department of Life, Health and Environmental Sciences of University of L´Aquila (Italy)
  • 2014-2016 Postdoctoral research fellow at the Institute of Environmental Medicine of Karolinska Institutet (Sweden)
  • 2010-2014 Postdoctoral research fellow at the Department of Translational Research and New Technologies in Medicine and Surgery, Medical Genetics Unit, of University of Pisa (Italy)
  • 2011 PhD in Cell and Molecular Biology, University of L´Aquila (Italy)
  • 2009 Erasmus Placement scholarship at the Institute Jacques Monod, University Paris Diderot (France)
  • 2008-2011 PhD candidate at the Department of Basic and Applied Biology, University of L´Aquila (Italy)


Key Publications

  • Pantzke J, Koch A, Zimmermann EJ, Rastak N, Offer S, Bisig C, Bauer S, Oeder S, Orasche J, Fiala P, Stintz M, Rüger CP, Streibel T, Di Bucchianico S, Zimmermann R. Processing of carbon-reinforced construction materials releases PM2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts. Environ Toxicol Pharmacol. 2023 Mar;98:104079.
  • Romano M, González Gómez MA, Santonicola P, Aloi N, Offer S, Pantzke J, Raccosta S, Longo V, Surpi A, Alacqua S, Zampi G, Dediu VA, Michalke B, Zimmerman R, Manno M, Piñeiro Y, Colombo P, Di Schiavi E, Rivas J, Bergese P, Di Bucchianico S. Synthesis and Characterization of a Biocompatible Nanoplatform Based on Silica-Embedded SPIONs Functionalized with Polydopamine. ACS Biomater Sci Eng. 2023 Jan 9;9(1):303-317.
  • Pantzke J, Offer S, Zimmermann EJ, Kuhn E, Streibel T, Oeder S, Di Bucchianico S, Zimmermann R. An alternative in vitro model considering cell-cell interactions in fiber-induced pulmonary fibrosis. Toxicol Mech Methods. 2022 Dec 15:1-16.
  • Offer S, Hartner E, Di Bucchianico S, Bisig C, Bauer S, Pantzke J, Zimmermann EJ, Cao X, Binder S, Kuhn E, Huber A, Jeong S, Käfer U, Martens P, Mesceriakovas A, Bendl J, Brejcha R, Buchholz A, Gat D, Hohaus T, Rastak N, Jakobi G, Kalberer M, Kanashova T, Hu Y, Ogris C, Marsico A, Theis F, Pardo M, Gröger T, Oeder S, Orasche J, Paul A, Ziehm T, Zhang ZH, Adam T, Sippula O, Sklorz M, Schnelle-Kreis J, Czech H, Kiendler-Scharr A, Rudich Y, Zimmermann R. Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air-Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs). Environ Health Perspect. 2022 Feb;130(2):27003.
  • Cao X, Padoan S, Binder S, Bauer S, Orasche J, Rus CM, Mudan A, Huber A, Kuhn E, Oeder S, Lintelmann J, Adam T, Di Bucchianico S, Zimmermann R. A comparative study of persistent DNA oxidation and chromosomal instability induced in vitro by oxidizers and reference airborne particles. Mutat Res Genet Toxicol Environ Mutagen. 2022 Feb-Mar;874-875:503446.
  • Di Bucchianico S, Gliga AR, Åkerlund E, Skoglund S, Wallinder IO, Fadeel B, Karlsson HL. Calcium-dependent cyto- and genotoxicity of nickel metal and nickel oxide nanoparticles in human lung cells. Part Fibre Toxicol. 2018 Jul 17;15(1):32.

University of Rostock
Institute of Chemistry
Division of Analytical and Technical Chemistry
& Department Life Light & Matter
Sebastiano Di Bucchianico
Albert-Einstein-Straße 27
18059 Rostock (Germany)


Tel.: +49 (0) 381 498 6535